Heparin as an hyperbolic modulator of plasminogen activation by t-PA


Journal Article

The effect of heparin on plasminogen activation, by t-PA, was re-exmamined using the Botts-Morales scheme for hyperbolic modulation. The modulation was found to be either positive, negative or non-existent depending on the presence of fibrin and the concentration of salt. Thermodynamic and kinetic parameters defining the modulation were derived computationally. Heparin appears to have a positive effect on plasminogen activation in solution, but no effect on plasminogen activation at the fibrin surface in physiological salt concentrations. © 1994 Longman Group Ltd.

Full Text

Duke Authors

Cited Authors

  • Pirie-Shepherd, SR; Blasco, E; Pizzo, SV

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 8 / 3

Start / End Page

  • 182 - 188

International Standard Serial Number (ISSN)

  • 0268-9499

Digital Object Identifier (DOI)

  • 10.1016/S0268-9499(05)80017-7

Citation Source

  • Scopus