Effect of verapamil on submissive behavior in genetically bred hypercholinergic rats in a water competition test.
Journal Article (Journal Article)
Male hypercholinergic FSL (Flinders Sensitive Line) and control FRL (Flinders Resistant Line) rats were placed on a water deprivation schedule and tested for dominance behavior with FSL/FRL pairs competing for water. FSL rats spent significantly less time drinking than their FRL partners. Acute injection of 10 mg/kg of verapamil, a calcium channel inhibitor, to FSL rats markedly increased their drinking time without influencing water intake in individually tested rats. This effect of the drug was no longer seen after prolonged 4 day treatment. It is suggested that submissiveness of FSL animals in the water competition test might be due to increased fear which is alleviated by verapamil treatment. Tolerance seems to develop to this effect of the drug.
Full Text
Duke Authors
Cited Authors
- Pucilowski, O; Overstreet, DH; Rezvani, AH; Janowsky, DS
Published Date
- October 23, 1990
Published In
Volume / Issue
- 187 / 3
Start / End Page
- 507 - 511
PubMed ID
- 2073924
International Standard Serial Number (ISSN)
- 0014-2999
Digital Object Identifier (DOI)
- 10.1016/0014-2999(90)90378-j
Language
- eng
Conference Location
- Netherlands