Impaired active avoidance responding in rats selectively bred for increased cholinergic function.

Journal Article (Journal Article)

It was found that the Flinders Sensitive Line (FSL) of rat, selectively bred for increased cholinergic function, performed poorly in a tone-cued two-way active avoidance task in comparison with the control Flinders Restraint Line (FRL) of rat. These findings are consistent with the suggestion that the FSL rats may be a genetic animal model of depression.

Full Text

Duke Authors

Cited Authors

  • Overstreet, DH; Rezvani, AH; Janowsky, DS

Published Date

  • April 1990

Published In

Volume / Issue

  • 47 / 4

Start / End Page

  • 787 - 788

PubMed ID

  • 2385654

International Standard Serial Number (ISSN)

  • 0031-9384

Digital Object Identifier (DOI)

  • 10.1016/0031-9384(90)90097-n


  • eng

Conference Location

  • United States