Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker?

Journal Article (Journal Article)

There is an overlap between alcoholism and depressive disorders. However, alcoholics tend to be resistant to the effect of cholinergic agonists, whereas depressives tend to be more sensitive. A recently developed animal model of depression which is more sensitive to cholinergic agonists is also more sensitive to the acute effects of ethanol. These consistent human and animal studies suggest that cholinergic challenges may be helpful in separating alcoholics from depressives.

Full Text

Duke Authors

Cited Authors

  • Overstreet, DH; Janowsky, DS; Rezvani, AH

Published Date

  • 1989

Published In

Volume / Issue

  • 24 / 3

Start / End Page

  • 253 - 255

PubMed ID

  • 2757700

International Standard Serial Number (ISSN)

  • 0735-0414


  • eng

Conference Location

  • England