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Divergent action of verapamil perfused in two hypothalamic areas on body temperature of the cat.

Publication ,  Journal Article
Beleslin, DB; Rezvani, AH; Myers, RD
Published in: Neurosci Lett
June 24, 1985

Guide cannulae for push-pull perfusion were bilaterally implanted stereotaxically within the anterior hypothalamic, preoptic area (AH/POA) and posterior hypothalamus (PH) of the cat. Catecholamine-reactive sites were identified within AH/POA in which a microinjection of norepinephrine (NE) (5.0 micrograms) evoked a characteristic, transient hypothermia. Similarly the cation-reactive region within the PH was identified in which excess Ca2+ (25 mM) also evoked a hypothermic response. When verapamil was perfused at a rate of 25.0 microliters/min in a concentration of 0.4 or 2.0 micrograms/microliter within AH/POA at a NE-sensitive site, a concentration-dependent decline in the core temperature of the cat occurred. Conversely, verapamil perfused in the same manner with a Ca2+-reactive site caused an intense rise in the cat's body temperature which also was concentration dependent. These results show that the localized blockade of slow Ca2+ channels exerts direct, differential physiological effects within central nervous system tissue. In this case, verapamil mimics noradrenergic effects within the AH/POA; however, the hyperthermic response following Ca2+ channel blockade within tissue of the PH resembled that produced by ethyleneglycoltetraacetic acid or Na ions.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

June 24, 1985

Volume

57

Issue

3

Start / End Page

307 / 312

Location

Ireland

Related Subject Headings

  • Verapamil
  • Preoptic Area
  • Hypothalamus, Posterior
  • Hypothalamus
  • Cats
  • Body Temperature
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3101 Biochemistry and cell biology
 

Citation

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Beleslin, D. B., Rezvani, A. H., & Myers, R. D. (1985). Divergent action of verapamil perfused in two hypothalamic areas on body temperature of the cat. Neurosci Lett, 57(3), 307–312. https://doi.org/10.1016/0304-3940(85)90510-5
Beleslin, D. B., A. H. Rezvani, and R. D. Myers. “Divergent action of verapamil perfused in two hypothalamic areas on body temperature of the cat.Neurosci Lett 57, no. 3 (June 24, 1985): 307–12. https://doi.org/10.1016/0304-3940(85)90510-5.
Beleslin DB, Rezvani AH, Myers RD. Divergent action of verapamil perfused in two hypothalamic areas on body temperature of the cat. Neurosci Lett. 1985 Jun 24;57(3):307–12.
Beleslin, D. B., et al. “Divergent action of verapamil perfused in two hypothalamic areas on body temperature of the cat.Neurosci Lett, vol. 57, no. 3, June 1985, pp. 307–12. Pubmed, doi:10.1016/0304-3940(85)90510-5.
Beleslin DB, Rezvani AH, Myers RD. Divergent action of verapamil perfused in two hypothalamic areas on body temperature of the cat. Neurosci Lett. 1985 Jun 24;57(3):307–312.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

June 24, 1985

Volume

57

Issue

3

Start / End Page

307 / 312

Location

Ireland

Related Subject Headings

  • Verapamil
  • Preoptic Area
  • Hypothalamus, Posterior
  • Hypothalamus
  • Cats
  • Body Temperature
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3101 Biochemistry and cell biology