Role of beta-endorphin in the control of body temperature in the rabbit.

Published

Journal Article

There is evidence of release of the opioid peptide beta-endorphin (beta-E) in the hypothalamus during development of fever and stress-induced hyperthermia. In the unanesthetized rabbit, microinjection of beta-E in the preoptic/anterior hypothalamus (POAH) results in peripheral vasoconstriction, inhibition of evaporative heat loss, and a prolonged elevation of body temperature. These reactions are magnified with increases in ambient temperature. Injections of beta-E nearly abolish vasodilation to back heating and also postural enhancement of heat dissipation ( sprawling , limb extension) in a hot environment. beta-E has also been found to reduce the thermal sensitivity of single POAH neurons to ambient heating. However, POAH beta-E injections do not alter metabolic rate at ambient temperatures from 2 to 27 degrees C, and to this extent beta-E-induced hyperthermia is distinct from fever. It is suggested that beta-E reduces sensitivity of POAH neurons to high ambient temperature and that this reduction leads to increased peripheral vasoconstriction, inhibition of evaporative heat loss, and modification of behavioral thermoregulation resulting in a regulated-type elevation in body temperature. A general neural model is proposed to explain the thermoregulatory effects of beta-E in the rabbit.

Full Text

Duke Authors

Cited Authors

  • Gordon, CJ; Rezvani, AH; Heath, JE

Published Date

  • 1984

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • 73 - 82

PubMed ID

  • 6328389

Pubmed Central ID

  • 6328389

International Standard Serial Number (ISSN)

  • 0149-7634

Language

  • eng

Conference Location

  • United States