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Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.

Publication ,  Journal Article
Lembo, G; Rockman, HA; Hunter, JJ; Steinmetz, H; Koch, WJ; Ma, L; Prinz, MP; Ross, J; Chien, KR; Powell-Braxton, L
Published in: J Clin Invest
December 1, 1996

To circumvent the embryonic lethality of a complete deficiency in insulin-like growth factor 1 (IGF-1), we generated mice homozygous for a site-specific insertional event that created a mutant IGF-1 allele (igf1m). These mice have IGF-1 levels 30% of wild type yet survive to adulthood, thereby allowing physiological analysis of the phenotype. Miniaturized catheterization technology revealed elevated conscious blood pressure in IGF-1(m/m) mice, and measurements of left ventricular contractility were increased. Adenylyl cyclase activity was enhanced in IGF-1(m/m) hearts, without an increase in beta-adrenergic receptor density, suggesting that crosstalk between IGF-1 and beta-adrenergic signaling pathways may mediate the increased contractility. The hypertrophic response of the left ventricular myocardium in response to aortic constriction, however, was preserved in IGF-1(m/m) mice. We conclude that chronic alterations in IGF-1 levels can selectively modulate blood pressure and left ventricular function, while not affecting adaptive myocardial hypertrophy in vivo.

Duke Scholars

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

December 1, 1996

Volume

98

Issue

11

Start / End Page

2648 / 2655

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Receptors, Adrenergic, beta
  • Polymerase Chain Reaction
  • Pituitary Gland
  • Myocardial Contraction
  • Mutagenesis, Site-Directed
  • Mutagenesis, Insertional
  • Mice, Mutant Strains
  • Mice
  • Male
 

Citation

APA
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Lembo, G., Rockman, H. A., Hunter, J. J., Steinmetz, H., Koch, W. J., Ma, L., … Powell-Braxton, L. (1996). Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J Clin Invest, 98(11), 2648–2655. https://doi.org/10.1172/JCI119086
Lembo, G., H. A. Rockman, J. J. Hunter, H. Steinmetz, W. J. Koch, L. Ma, M. P. Prinz, J. Ross, K. R. Chien, and L. Powell-Braxton. “Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.J Clin Invest 98, no. 11 (December 1, 1996): 2648–55. https://doi.org/10.1172/JCI119086.
Lembo G, Rockman HA, Hunter JJ, Steinmetz H, Koch WJ, Ma L, et al. Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J Clin Invest. 1996 Dec 1;98(11):2648–55.
Lembo, G., et al. “Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.J Clin Invest, vol. 98, no. 11, Dec. 1996, pp. 2648–55. Pubmed, doi:10.1172/JCI119086.
Lembo G, Rockman HA, Hunter JJ, Steinmetz H, Koch WJ, Ma L, Prinz MP, Ross J, Chien KR, Powell-Braxton L. Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J Clin Invest. 1996 Dec 1;98(11):2648–2655.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

December 1, 1996

Volume

98

Issue

11

Start / End Page

2648 / 2655

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Receptors, Adrenergic, beta
  • Polymerase Chain Reaction
  • Pituitary Gland
  • Myocardial Contraction
  • Mutagenesis, Site-Directed
  • Mutagenesis, Insertional
  • Mice, Mutant Strains
  • Mice
  • Male