A noninvasive method for delivering controlled doses of nicotine via cigarette smoke

Published

Journal Article

A cigarette-smoke delivery system is described in which nicotine dosage was delimited by having the subject inhale a measured amount of smoke to a predetermined depth and duration of inhalation. A plastic syringe was used to "inject" a specified amount of cigarette smoke into the subject's mouth, and an airbag containing 1 liter of air was used to provide a "chaser" with a fixed volume of inhalation for the smoke. Using plasma nicotine boost as an indicator, dose control was found to be nearly linear for the three dose levels employed; in the high-dose condition, plasma nicotine levels were moderately consistent within subjects over three successive administrations. Between-subject variability was considerably greater than within-subject variability, however, suggesting that each smoker obtained a characteristic nicotine boost that reflected individual differences in nicotine pharmacokinetics in addition to nicotine intake per se. © 1989 Psychonomic Society, Inc.

Full Text

Duke Authors

Cited Authors

  • Pomerleau, OF; Rose, JE; Pomerleau, CS; Majchrzak, MJ

Published Date

  • November 1, 1989

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 598 - 602

Electronic International Standard Serial Number (EISSN)

  • 1532-5970

International Standard Serial Number (ISSN)

  • 0743-3808

Digital Object Identifier (DOI)

  • 10.3758/BF03210582

Citation Source

  • Scopus