Solid-organ transplantation in older adults: current status and future research.

Journal Article

An increasing number of patients older than 65 years are referred for and have access to organ transplantation, and an increasing number of older adults are donating organs. Although short-term outcomes are similar in older versus younger transplant recipients, older donor or recipient age is associated with inferior long-term outcomes. However, age is often a proxy for other factors that might predict poor outcomes more strongly and better identify patients at risk for adverse events. Approaches to transplantation in older adults vary across programs, but despite recent gains in access and the increased use of marginal organs, older patients remain less likely than other groups to receive a transplant, and those who do are highly selected. Moreover, few studies have addressed geriatric issues in transplant patient selection or management, or the implications on health span and disability when patients age to late life with a transplanted organ. This paper summarizes a recent trans-disciplinary workshop held by ASP, in collaboration with NHLBI, NIA, NIAID, NIDDK and AGS, to address issues related to kidney, liver, lung, or heart transplantation in older adults and to propose a research agenda in these areas.

Full Text

Duke Authors

Cited Authors

  • Abecassis, M; Bridges, ND; Clancy, CJ; Dew, MA; Eldadah, B; Englesbe, MJ; Flessner, MF; Frank, JC; Friedewald, J; Gill, J; Gries, C; Halter, JB; Hartmann, EL; Hazzard, WR; Horne, FM; Hosenpud, J; Jacobson, P; Kasiske, BL; Lake, J; Loomba, R; Malani, PN; Moore, TM; Murray, A; Nguyen, M-H; Powe, NR; Reese, PP; Reynolds, H; Samaniego, MD; Schmader, KE; Segev, DL; Shah, AS; Singer, LG; Sosa, JA; Stewart, ZA; Tan, JC; Williams, WW; Zaas, DW; High, KP

Published Date

  • October 2012

Published In

Volume / Issue

  • 12 / 10

Start / End Page

  • 2608 - 2622

PubMed ID

  • 22958872

Pubmed Central ID

  • 22958872

Electronic International Standard Serial Number (EISSN)

  • 1600-6143

Digital Object Identifier (DOI)

  • 10.1111/j.1600-6143.2012.04245.x


  • eng

Conference Location

  • United States