Cartilage metalloproteases in disuse atrophy.

Journal Article

A canine knee model of disuse atrophy produced by nonrigid fixation (sling) was characterized in respect to variables of proteoglycan size distribution, as well as biomechanical properties versus controls. Using this model, we found, in addition to the accepted dogma attributing changes to reduced protein synthesis by chondrocytes, that there is elevation of proteases and depression of tissue inhibitor of metalloproteases (TIMP) in atrophic knee cartilage. The findings are suggestive of cartilage remodelling reminiscent of bone remodelling in disuse atrophy reported by others. Whether the abnormal changes of protease-TIMP balance in knee cartilage can be retarded prophylactically by concurrent treatment with pentosan polysulfate and insulin like growth factor 1 remains uncertain.

Duke Authors

Cited Authors

  • Grumbles, RM; Howell, DS; Howard, GA; Roos, BA; Setton, LA; Mow, VC; Ratcliffe, A; Muller, FJ; Altman, RD

Published Date

  • February 1995

Published In

Volume / Issue

  • 43 /

Start / End Page

  • 146 - 148

PubMed ID

  • 7538586

International Standard Serial Number (ISSN)

  • 0380-0903

Language

  • eng

Citation Source

  • PubMed