Bretylium tosylate enhances salt taste.
Journal Article
Bretylium tosylate (BT), an antifibrillary drug, was found to potentiate the taste of NaCl and LiCl in both humans and rats. Application of 1 mM BT (pH 6.3) to the human tongue statistically potentiated the taste of 0.2 M NaCl and 0.2 M LiCl by 33.5% and 12.5% respectively. Electrophysiological taste responses from nucleus tractus solitarius (NTS) in rat for both hyposmotic and hyperosmotic concentrations of NaCl and 0.1 M LiCl were also increased by 30 to 40% after application of 1 mM BT. This potentiation induced by BT was reduced by amiloride in both humans and rats. Furthermore, amiloride became ineffective in inhibiting taste responses to NaCl in the presence of BT.
Full Text
Duke Authors
Cited Authors
- Schiffman, SS; Simon, SA; Gill, JM; Beeker, TG
Published Date
- 1986
Published In
Volume / Issue
- 36 / 6
Start / End Page
- 1129 - 1137
PubMed ID
- 3725917
Pubmed Central ID
- 3725917
International Standard Serial Number (ISSN)
- 0031-9384
Digital Object Identifier (DOI)
- 10.1016/0031-9384(86)90490-7
Language
- eng
Conference Location
- United States