Bretylium tosylate enhances salt taste.

Published

Journal Article

Bretylium tosylate (BT), an antifibrillary drug, was found to potentiate the taste of NaCl and LiCl in both humans and rats. Application of 1 mM BT (pH 6.3) to the human tongue statistically potentiated the taste of 0.2 M NaCl and 0.2 M LiCl by 33.5% and 12.5% respectively. Electrophysiological taste responses from nucleus tractus solitarius (NTS) in rat for both hyposmotic and hyperosmotic concentrations of NaCl and 0.1 M LiCl were also increased by 30 to 40% after application of 1 mM BT. This potentiation induced by BT was reduced by amiloride in both humans and rats. Furthermore, amiloride became ineffective in inhibiting taste responses to NaCl in the presence of BT.

Full Text

Duke Authors

Cited Authors

  • Schiffman, SS; Simon, SA; Gill, JM; Beeker, TG

Published Date

  • 1986

Published In

Volume / Issue

  • 36 / 6

Start / End Page

  • 1129 - 1137

PubMed ID

  • 3725917

Pubmed Central ID

  • 3725917

International Standard Serial Number (ISSN)

  • 0031-9384

Digital Object Identifier (DOI)

  • 10.1016/0031-9384(86)90490-7

Language

  • eng

Conference Location

  • United States