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Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.

Publication ,  Journal Article
Snyderman, R; Smith, CD; Verghese, MW
Published in: J Leukoc Biol
December 1986

Binding of chemoattractants to their receptors on phagocytes activates a guanine nucleotide regulatory (N) protein through the substitution of GTP for GDP on N. The activated N protein in turn stimulates a membrane-associated phospholipase C by lowering the Ca2+ concentration required to activate this enzyme from supraphysiologic levels to ambient intracellular concentrations. The phospholipase C hydrolyzes phosphatidylinositol 4,5-bisphosphate into the Ca2+ mobilizer inositol 1,4,5-trisphosphate and the protein kinase C activator 1,2-diacylglycerol. In addition to promoting cellular activation, the products of this hydrolysis initiate processes which feed back to inhibit poly-phosphoinositide breakdown. The regulatory model proposed herein may be relevant to other receptors which stimulate polyphosphoinositide metabolism.

Duke Scholars

Published In

J Leukoc Biol

DOI

ISSN

0741-5400

Publication Date

December 1986

Volume

40

Issue

6

Start / End Page

785 / 800

Location

England

Related Subject Headings

  • Receptors, Immunologic
  • Receptors, Formyl Peptide
  • Protein Kinases
  • Phosphatidylinositols
  • Phagocytosis
  • Models, Biological
  • Leukocytes
  • Immunology
  • GTP-Binding Proteins
  • Cyclic AMP
 

Citation

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Snyderman, R., Smith, C. D., & Verghese, M. W. (1986). Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. J Leukoc Biol, 40(6), 785–800. https://doi.org/10.1002/jlb.40.6.785
Snyderman, R., C. D. Smith, and M. W. Verghese. “Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.J Leukoc Biol 40, no. 6 (December 1986): 785–800. https://doi.org/10.1002/jlb.40.6.785.
Snyderman, R., et al. “Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.J Leukoc Biol, vol. 40, no. 6, Dec. 1986, pp. 785–800. Pubmed, doi:10.1002/jlb.40.6.785.

Published In

J Leukoc Biol

DOI

ISSN

0741-5400

Publication Date

December 1986

Volume

40

Issue

6

Start / End Page

785 / 800

Location

England

Related Subject Headings

  • Receptors, Immunologic
  • Receptors, Formyl Peptide
  • Protein Kinases
  • Phosphatidylinositols
  • Phagocytosis
  • Models, Biological
  • Leukocytes
  • Immunology
  • GTP-Binding Proteins
  • Cyclic AMP