Disorders of leukocyte chemotaxis.


Journal Article (Review)

The rapid accumulation of inflammatory cells at sites of microbial invasion or neoplastic transformation is a central event in immunologically-mediated host defense. The availability of methodology to accurately quantify leukocyte migration in vitro has allowed the disclosure of previously unrecognized clinical disorders, namely leukocyte dysmotility syndromes. Although this area of clinical investigation is in its infancy, one can identify several processes associated with abnormal leukocyte accumulation. Abnormalities of immune recognition, chemotactic factor production, cellular motility or inhibitors of chemotaxis have been identified in different human diseases. In the upcoming years, pharmacological intervention directed at correcting specific causes of leukocyte dysmotility may well enhance our ability to treat certain infectious, inflammatory, and neoplastic diseases.

Full Text

Duke Authors

Cited Authors

  • Snyderman, R; Pike, MC

Published Date

  • May 1, 1977

Published In

Volume / Issue

  • 24 / 2

Start / End Page

  • 377 - 393

PubMed ID

  • 323806

Pubmed Central ID

  • 323806

International Standard Serial Number (ISSN)

  • 0031-3955


  • eng

Conference Location

  • United States