Further characterization of a factor from endotoxin-treated serum which releases histamine and heparin from mast cells.

Journal Article (Journal Article)

Upon incubation of hamster serum with bacterial endotoxin, a factor is produced which releases histamine and heparin from hamster mast cells and increases capillary permeability in guinea pig skin. The major histamine-releasing activity derived from hamster serum was characterized by gel filtration, found to have a molecular weight of approximately 60,000, and shown by electrophoresis to migrate with alpha-2- or beta-1-globulins. The ability to increase vascular permeability was not reversed by antihistamine. On the basis of these properties, the histamine-liberating factor generated by endotoxin in hamster serum differed significantly from known anaphylatoxins.

Full Text

Duke Authors

Cited Authors

  • Hook, WA; Snyderman, R; Mergenhagen, SE

Published Date

  • June 1, 1972

Published In

Volume / Issue

  • 5 / 6

Start / End Page

  • 909 - 914

PubMed ID

  • 4117883

Pubmed Central ID

  • PMC422462

International Standard Serial Number (ISSN)

  • 0019-9567

Digital Object Identifier (DOI)

  • 10.1128/iai.5.6.909-914.1972


  • eng

Conference Location

  • United States