Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells.
Journal Article
Infection of primary rabbit kidney cells with herpes simplex virus leads to the release of a cell factor or factors that upon incubation with serum results in the cleavage of the fifth component, C5, of complement. The product of this cleavage, C5a, is chemotactic for polymorphonuclear leukocytes and could be responsible for the accumulation of these cells at the site of herpetic lesions.
Full Text
Duke Authors
Cited Authors
- Brier, AM; Snyderman, R; Mergenhagen, SE; Notkins, AL
Published Date
- December 4, 1970
Published In
Volume / Issue
- 170 / 3962
Start / End Page
- 1104 - 1106
PubMed ID
- 4319925
Pubmed Central ID
- 4319925
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.170.3962.1104
Language
- eng
Conference Location
- United States