Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells.

Journal Article

Infection of primary rabbit kidney cells with herpes simplex virus leads to the release of a cell factor or factors that upon incubation with serum results in the cleavage of the fifth component, C5, of complement. The product of this cleavage, C5a, is chemotactic for polymorphonuclear leukocytes and could be responsible for the accumulation of these cells at the site of herpetic lesions.

Full Text

Duke Authors

Cited Authors

  • Brier, AM; Snyderman, R; Mergenhagen, SE; Notkins, AL

Published Date

  • December 4, 1970

Published In

Volume / Issue

  • 170 / 3962

Start / End Page

  • 1104 - 1106

PubMed ID

  • 4319925

Pubmed Central ID

  • 4319925

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.170.3962.1104


  • eng

Conference Location

  • United States