Neutralization of sensitized virus by the fourth component of complement.

Journal Article (Journal Article)

Herpes simplex virus which had been sensitized with IgM antibody was not neutralized by the addition of the purified activated first component of complement. In the presence of an optimum concentration of the first component of complement, however, the sensitized virus was neutralized by the addition of a high concentration of the purified fourth component of complement. Under these conditions, the addition of the purified second and third components of complement failed to enhance virus neutralization. With low concentrations of the fourth component of complement, the addition of the second and third components enhanced virus neutralization.

Full Text

Duke Authors

Cited Authors

  • Daniels, CA; Borsos, T; Rapp, HJ; Snyderman, R; Notkins, AL

Published Date

  • August 1, 1969

Published In

Volume / Issue

  • 165 / 3892

Start / End Page

  • 508 - 509

PubMed ID

  • 4183180

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.165.3892.508


  • eng

Conference Location

  • United States