Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement.

Journal Article (Journal Article)

The fifth component of guinea pig complement, with a sedimentation coefficient 7.8S, is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4S and 1.5S. The smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig ileum.

Full Text

Duke Authors

Cited Authors

  • Shin, HS; Snyderman, R; Friedman, E; Mellors, A; Mayer, MM

Published Date

  • October 18, 1968

Published In

Volume / Issue

  • 162 / 3851

Start / End Page

  • 361 - 363

PubMed ID

  • 4175690

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.162.3851.361


  • eng

Conference Location

  • United States