Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression.


Journal Article

Changes in the pH of interstitial fluid were measured with H+-selective double-barreled micropipette electrodes in fascia dentata of urethane-anesthetized rats. Paroxysmal afterdischarges provoked by repetitive stimulation of an afferent fiber tract brought in their wake acidification by 0.07 to 0.2 pH units. Spreading depression caused acidification by 0.2-0.5 pH units. Acid shifts were often preceded by transient alkalinization. Acidification is attributed to the production of CO2 and of other acid metabolites.

Full Text

Duke Authors

Cited Authors

  • Somjen, GG

Published Date

  • October 8, 1984

Published In

Volume / Issue

  • 311 / 1

Start / End Page

  • 186 - 188

PubMed ID

  • 6488041

Pubmed Central ID

  • 6488041

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(84)91416-1


  • eng

Conference Location

  • Netherlands