Hippocampal volume as a predictor of short-term ECT outcomes in older patients with depression.
OBJECTIVE: The authors examined the relationship between hippocampal volume and acute electroconvulsive therapy (ECT) outcomes. METHODS: Depression was measured by Montgomery-Asberg Depression Rating Scale (MADRS) scores, and hippocampal volume was assessed by magnetic resonance imaging. RESULTS: After controlling for baseline MADRS score, larger right-hippocampal volume was associated with higher MADRS scores after an index course of ECT. CONCLUSION: These results are the converse of those obtained in a study assessing the relationship between hippocampal volume and pharmacotherapy. The findings suggest a need for further study in this area.
Lekwauwa, RE; McQuoid, DR; Steffens, DC
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