Will neurotrophic agents be harmful in Alzheimer's disease?

Journal Article (Journal Article)

The thesis that neurotrophic therapy in Alzheimer's disease may exacerbate the pathological state merits careful experimental verification. We are concerned about prematurely dismissing an important avenue of potential therapy which would provide a trophic stimulus to compensate for enhanced proteolysis and the deposition of A4 amyloid peptide.

Full Text

Duke Authors

Cited Authors

  • Appel, SH; McManaman, JL; Strittmatter, WJ

Published Date

  • 1989

Published In

Volume / Issue

  • 10 / 5

Start / End Page

  • 580 - 581

PubMed ID

  • 2812232

International Standard Serial Number (ISSN)

  • 0197-4580

Digital Object Identifier (DOI)

  • 10.1016/0197-4580(89)90136-x


  • eng

Conference Location

  • United States