Rat myoblast fusion requires metalloendoprotease activity.
Journal Article
The calcium-dependent fusion of cultured rat myoblasts to multinucleate myotubes appears to require the activity of a neutral metalloendoprotease at the time of fusion. Metalloendoprotease inhibitors and synthetic dipeptide substrates prevent myoblast fusion when added to fusion-competent myoblasts with the addition of calcium. Metalloendoprotease activity has been identified and partially characterized in myoblast membranes with a fluorogenic protease substrate, and is inhibited by the same compounds that prevent fusion.
Full Text
Duke Authors
Cited Authors
- Couch, CB; Strittmatter, WJ
Published Date
- January 1, 1983
Published In
Volume / Issue
- 32 / 1
Start / End Page
- 257 - 265
PubMed ID
- 6337722
Pubmed Central ID
- 6337722
International Standard Serial Number (ISSN)
- 0092-8674
Digital Object Identifier (DOI)
- 10.1016/0092-8674(83)90516-0
Language
- eng
Conference Location
- United States