Rat myoblast fusion requires metalloendoprotease activity.

Journal Article (Journal Article)

The calcium-dependent fusion of cultured rat myoblasts to multinucleate myotubes appears to require the activity of a neutral metalloendoprotease at the time of fusion. Metalloendoprotease inhibitors and synthetic dipeptide substrates prevent myoblast fusion when added to fusion-competent myoblasts with the addition of calcium. Metalloendoprotease activity has been identified and partially characterized in myoblast membranes with a fluorogenic protease substrate, and is inhibited by the same compounds that prevent fusion.

Full Text

Duke Authors

Cited Authors

  • Couch, CB; Strittmatter, WJ

Published Date

  • January 1, 1983

Published In

Volume / Issue

  • 32 / 1

Start / End Page

  • 257 - 265

PubMed ID

  • 6337722

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(83)90516-0


  • eng

Conference Location

  • United States