Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids.

Journal Article (Journal Article)

Stimulation of the beta-adrenergic receptor increases the enzymatic methylation of membrane phospholipids. Increased synthesis of phosphatidyl-N-monomethylethanolamine by methyltransferase I increases fluidity and enhances the ability of the beta-adrenergic receptor to couple with adenylate cyclase. The number of beta-adrenergic receptors can be regulated by the rate of synthesis and of degradation of phosphatidylcholine formed by transmethylation.

Full Text

Duke Authors

Cited Authors

  • Strittmatter, WJ; Hirata, F; Axelrod, J

Published Date

  • 1981

Published In

Volume / Issue

  • 14 /

Start / End Page

  • 83 - 91

PubMed ID

  • 6269406

International Standard Serial Number (ISSN)

  • 0084-5930


  • eng

Conference Location

  • United States