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Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes.

Publication ,  Journal Article
Strittmatter, WJ; Hirata, F; Axelrod, J
Published in: Science
June 15, 1979

The effect of phospholipid methylation on the number of beta-adrenergic receptor binding sites was examined in rat reticulocyte membranes. Stimulation of phosphatidylcholine synthesis by the introduction of the methyl donor S-adenosyl-L-methionine into reticulocyte ghosts increased the number of beta-adrenergic receptor sites. The appearance of beta-adrenergic binding sites was dependent on the formation of phosphatidylcholine by the enzyme that converts phosphatidyl-N-monomethylethanolamine from phosphatidylethanolamine. Both the synthesis of phosphatidylcholine and the unmasking of cryptic receptors were time and temperature dependent and did not occur in the presence of the methyl transferase inhibitor, S-adenosyl-L-homocysteine.

Duke Scholars

Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 15, 1979

Volume

204

Issue

4398

Start / End Page

1205 / 1207

Location

United States

Related Subject Headings

  • S-Adenosylmethionine
  • Reticulocytes
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Rats
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Methyltransferases
  • Methylation
 

Citation

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Strittmatter, W. J., Hirata, F., & Axelrod, J. (1979). Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. Science, 204(4398), 1205–1207. https://doi.org/10.1126/science.221977
Strittmatter, W. J., F. Hirata, and J. Axelrod. “Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes.Science 204, no. 4398 (June 15, 1979): 1205–7. https://doi.org/10.1126/science.221977.
Strittmatter WJ, Hirata F, Axelrod J. Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. Science. 1979 Jun 15;204(4398):1205–7.
Strittmatter, W. J., et al. “Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes.Science, vol. 204, no. 4398, June 1979, pp. 1205–07. Pubmed, doi:10.1126/science.221977.
Strittmatter WJ, Hirata F, Axelrod J. Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. Science. 1979 Jun 15;204(4398):1205–1207.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 15, 1979

Volume

204

Issue

4398

Start / End Page

1205 / 1207

Location

United States

Related Subject Headings

  • S-Adenosylmethionine
  • Reticulocytes
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Rats
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Methyltransferases
  • Methylation