Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes.

Journal Article (Journal Article)

The effect of phospholipid methylation on the number of beta-adrenergic receptor binding sites was examined in rat reticulocyte membranes. Stimulation of phosphatidylcholine synthesis by the introduction of the methyl donor S-adenosyl-L-methionine into reticulocyte ghosts increased the number of beta-adrenergic receptor sites. The appearance of beta-adrenergic binding sites was dependent on the formation of phosphatidylcholine by the enzyme that converts phosphatidyl-N-monomethylethanolamine from phosphatidylethanolamine. Both the synthesis of phosphatidylcholine and the unmasking of cryptic receptors were time and temperature dependent and did not occur in the presence of the methyl transferase inhibitor, S-adenosyl-L-homocysteine.

Full Text

Duke Authors

Cited Authors

  • Strittmatter, WJ; Hirata, F; Axelrod, J

Published Date

  • June 15, 1979

Published In

Volume / Issue

  • 204 / 4398

Start / End Page

  • 1205 - 1207

PubMed ID

  • 221977

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.221977


  • eng

Conference Location

  • United States