Marrow transplantation for chronic myeloid leukemia: A randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide

Journal Article

A prospective randomized study was conducted comparing two conditioning regimens for the treatment of patients with chronic myeloid leukemia in chronic phase by marrow transplantation from HLA identical siblings. Sixty- nine patients received 60 mg/kg of cyclophosphamide on each of 2 successive days followed by 6 fractions of total body irradiation each of 2.0 Gy (CY- TBI), and 73 patients received 16 mg/kg of busulfan delivered over 4 days followed by 60 mg/kg CY on each of 2 successive days (BU-CY). There was no significant difference between the CY-TBI and the BU-CY groups in the 3-year probabilities of survival (0.80 for both), relapse (0.13 for both), or event- free survival (CY-TBI, 0.68; BU-CY, 0.71) or in speed of engraftment or incidence of venocclusive disease of the liver. The 4-year probabilities of survival and event-free survival for patients transplanted within 1 year of diagnosis were 0.86 and 0.72, respectively, for each group. Significantly more patients in the CY-TBI group experienced major creatinine elevations. There was significantly more acute graft-versus-host disease in the CY-TBI group. Fever days, positive blood cultures, hospitalizations, and inpatient hospital days were significantly more common in the CY-TBI group than in the BU-CY group. In conclusion, the BU-CY regimen was better tolerated than, and associated with survival and relapse probabilities that compare favorably with, the CY-TBI regimen.

Duke Authors

Cited Authors

  • Clift, RA; Buckner, CD; Thomas, ED; Bensinger, WI; Bowden, R; Bryant, E; Deeg, HJ; Doney, KC; Fisher, LD; Hansen, JA; Martin, P; McDonald, GB; Sanders, JE; Schoch, G; Singer, J; Storb, R; Sullivan, KM; Witherspoon, RP; Appelbaum, FR

Published Date

  • 1994

Published In

Volume / Issue

  • 84 / 6

Start / End Page

  • 2036 - 2043

PubMed ID

  • 8081005

International Standard Serial Number (ISSN)

  • 0006-4971