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Graft versus leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation.

Publication ,  Journal Article
Fefer, A; Sullivan, KM; Weiden, P; Buckner, CD; Schoch, G; Storb, R; Thomas, ED
Published in: Prog Clin Biol Res
1987

To determine whether allogeneic bone marrow transplantation (BMT) is associated with a graft vs leukemia (GVL) effect in man, the relapse rate of acute leukemia after allogeneic BMT was compared with that occurring after syngeneic (genetically identical twin) BMT. The patients had ALL or ANL in second or subsequent complete remission (CR) or in relapse. The allogeneic and syngeneic marrow recipients were comparable in diagnosis, age, and interval from diagnosis to BMT and received comparable chemoradiotherapy regimens. Allogeneic marrow recipients, however, received, in addition, GVH disease prophylaxis, most often methotrexate and, more recently, cyclosporine or both. All patients treated by the Seattle team from 1970-1986 are included. Leukemic recurrence was observed in 62% of 785 allogeneic recipients and 75% of 53 syngeneic recipients (p less than 0.0001). The results confirm the circumstantial evidence for a GVL effect exerted by allogeneic marrow. Analyses are in progress to determine whether a GVL effect exists in subsets of patients as a function of their particular diagnosis or status at the time of BMT.

Duke Scholars

Published In

Prog Clin Biol Res

ISSN

0361-7742

Publication Date

1987

Volume

244

Start / End Page

401 / 408

Location

United States

Related Subject Headings

  • Twins, Monozygotic
  • Transplantation, Isogeneic
  • Transplantation, Homologous
  • Leukemia
  • Immunotherapy
  • Humans
  • Graft vs Host Disease
  • Bone Marrow Transplantation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fefer, A., Sullivan, K. M., Weiden, P., Buckner, C. D., Schoch, G., Storb, R., & Thomas, E. D. (1987). Graft versus leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation. Prog Clin Biol Res, 244, 401–408.
Fefer, A., K. M. Sullivan, P. Weiden, C. D. Buckner, G. Schoch, R. Storb, and E. D. Thomas. “Graft versus leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation.Prog Clin Biol Res 244 (1987): 401–8.
Fefer A, Sullivan KM, Weiden P, Buckner CD, Schoch G, Storb R, et al. Graft versus leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation. Prog Clin Biol Res. 1987;244:401–8.
Fefer A, Sullivan KM, Weiden P, Buckner CD, Schoch G, Storb R, Thomas ED. Graft versus leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation. Prog Clin Biol Res. 1987;244:401–408.

Published In

Prog Clin Biol Res

ISSN

0361-7742

Publication Date

1987

Volume

244

Start / End Page

401 / 408

Location

United States

Related Subject Headings

  • Twins, Monozygotic
  • Transplantation, Isogeneic
  • Transplantation, Homologous
  • Leukemia
  • Immunotherapy
  • Humans
  • Graft vs Host Disease
  • Bone Marrow Transplantation