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Antithymocyte globulin followed by cyclosporine for the treatment of acute GVHD in patients given HLA-identical or -nonidentical marrow grafts

Publication ,  Journal Article
Deeg, HJ; Doney, K; Sullivan, KM
Published in: Transplantation Proceedings
January 1, 1986

Graft-v-host disease (GVHD) remains a major complication after allogeneic marrow transplantation. Between 30% and 60% of patients given unmanipulated marrow from an HLA-identical sibling donor and 80% of patients transplanted from an HLA-nonidentical donor and given postgrafting immunosuppression with a single agent develop acute GVHD requiring therapy. We carried out a study in which patients with acute GVHD were given ATG followed by CsA with or without the addition of MP. Two thirds of patients responded to therapy, and long-term survival was better than in patients treated in the past with single-agent therapy. This report presents follow-up data on the patient population observed now for 15 to 30 months after transplantation.

Duke Scholars

Published In

Transplantation Proceedings

ISSN

0041-1345

Publication Date

January 1, 1986

Volume

18

Issue

4

Start / End Page

791 / 793

Related Subject Headings

  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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ICMJE
MLA
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Deeg, H. J., Doney, K., & Sullivan, K. M. (1986). Antithymocyte globulin followed by cyclosporine for the treatment of acute GVHD in patients given HLA-identical or -nonidentical marrow grafts. Transplantation Proceedings, 18(4), 791–793.
Deeg, H. J., K. Doney, and K. M. Sullivan. “Antithymocyte globulin followed by cyclosporine for the treatment of acute GVHD in patients given HLA-identical or -nonidentical marrow grafts.” Transplantation Proceedings 18, no. 4 (January 1, 1986): 791–93.
Deeg, H. J., et al. “Antithymocyte globulin followed by cyclosporine for the treatment of acute GVHD in patients given HLA-identical or -nonidentical marrow grafts.” Transplantation Proceedings, vol. 18, no. 4, Jan. 1986, pp. 791–93.
Journal cover image

Published In

Transplantation Proceedings

ISSN

0041-1345

Publication Date

January 1, 1986

Volume

18

Issue

4

Start / End Page

791 / 793

Related Subject Headings

  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences