Myasthenia gravis after allogeneic bone marrow transplantation: Relationship to chronic graft-versus-host disease

Journal Article

Three patients with chronic graft-versus-host disease (GVHD) developed myasthenia gravis (MG) 762 to 1,180 days after allogeneic bone marrow transplantation. Symptoms of MG were observed after taper or discontinuation of immunosuppressive treatment of chronic GVHD. All patients developed antibodies to acetylcholine receptor, and one had antibody formation to striated muscle. One patient died of complications of treatment of MG. The severity of disease underscores the importance of the differential diagnosis and the need for prompt therapy of this late complication after human bone marrow transplantation.

Duke Authors

Cited Authors

  • Bolger, GB; Sullivan, KM; Spence, AM; Appelbaum, FR; Johnston, R; Sanders, JE; Deeg, HJ; Witherspoon, RP; Doney, KC; Nims, J

Published Date

  • 1986

Published In

Volume / Issue

  • 36 / 8

Start / End Page

  • 1087 - 1091

PubMed ID

  • 3526178

International Standard Serial Number (ISSN)

  • 0028-3878