Allogeneic marrow transplantation in the treatment of MOPP-resistant Hodgkin's disease

Journal Article

Eight patients with disseminated Hodgkin's disease resistant to MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) chemotherapy were treated with high-dose chemoradiotherapy and marrow transplantation from an HLA-identical sibling. Two patients remain alive in unmaintained complete remission (CR) at 38 and 39 months after transplant. In the other six patients, reasons for failure included relapse of lymphoma (two patients), or death due to complications of the transplant procedure, including Legionnaire's disease, disseminated zoster, graft-v-host disease, and aspiration pneumonia secondary to severe mucositis. These results demonstrate that some patients with MOPP-resistant Hodgkin's disease can obtain prolonged CR following intensive chemoradiotherapy and allogeneic marrow transplantation.

Duke Authors

Cited Authors

  • Appelbaum, FR; Sullivan, KM; Thomas, ED; Buckner, CD; Clift, RA; Deeg, HJ; Neiman, PE; Sanders, JE; Stewart, P; Storb, R

Published Date

  • 1985

Published In

Volume / Issue

  • 3 / 11

Start / End Page

  • 1490 - 1494

PubMed ID

  • 2414410

International Standard Serial Number (ISSN)

  • 0732-183X