Chronic cutaneous graft-versus-host disease in man.

Journal Article (Journal Article)

This clinicopathologic study of patients with chronic graft-versus-host disease (GVHD) after allogeneic marrow transplantation emphasizes the most prominent feature of the syndrome, the cutaneous aspects, and describes the ophthalmic-oral sicca syndrome with sialoadenitis and the neurologic findings. Chronic cutaneous GVHD affected 19 of 92 recipients surviving 150 days or more. In 6 patients chronic GVHD presented as a continuation of acute GVHD; in 8 it occurred after the resolution of acute GVHD; and in 5 it arose without preceding acute GVHD, ie, de novo late onset. Two cutaneous types were distinguished. The generalized type affected 16 patients and ran a progressive course resulting in late complications of poikiloderma, diffuse dermal and subcutaneous fibrosis, and contractures. Microscopically, it resembled generalized morphea and lupus erythermatosus hypertrophicus et profundus. The local type affected 3 patients with a more variable picture of poikiloderma, dermal sclerosis, and contractures. Microscopically, it resembled lupus of erythematosus profundus and scleroderma. Guidelines for defining and subclassifying chronic cutaneous GVHD are proposed.

Full Text

Duke Authors

Cited Authors

  • Shulman, HM; Sale, GE; Lerner, KG; Barker, EA; Weiden, PL; Sullivan, K; Gallucci, B; Thomas, ED; Storb, R

Published Date

  • June 1978

Published In

Volume / Issue

  • 91 / 3

Start / End Page

  • 545 - 570

PubMed ID

  • 26221

Pubmed Central ID

  • PMC2018320

International Standard Serial Number (ISSN)

  • 0002-9440


  • eng

Conference Location

  • United States