Kainic acid lesioning of alkaloid-sensitive brain sites and ethanol ingestion in the rat.

Journal Article (Journal Article)

A control alcohol (ethanol) preference test was first given to adult male Sprague-Dawley rats which were provided water together with alcohol increased in concentrations from 3 to 30% over 8 days. Then each rat was anesthetized and a two-stage, bilateral lesion was made stereotaxically by microinjection of kainic acid in a dose of 0.5 micrograms into the hippocampus, cingulate gyrus or periaqueductal gray. Specifically selected sites were based on earlier experiments in which the application of a tetrahydroisoquinoline alkaloid was found to induce an increase in alcohol drinking. Two weeks later, the 8-day test of self-selection for alcohol was repeated. Although neurological signs of kainic acid lesions were apparent, no significant differences in alcohol drinking in terms of proportion or g/kg intake occurred after either the first or second stage of the lesion. These results show that local destruction of an alkaloid-sensitive site does not appear to be responsible for induction of aberrant drinking of alcohol.

Full Text

Duke Authors

Cited Authors

  • Swartzwelder, HS; Myers, RD

Published Date

  • March 28, 1983

Published In

Volume / Issue

  • 36 / 1

Start / End Page

  • 99 - 104

PubMed ID

  • 6856206

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(83)90493-7


  • eng

Conference Location

  • Ireland