Acute treatment with trimethyltin alters alcohol self-selection.

Journal Article (Journal Article)

Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-treated rat consistently drank less alcohol than did the controls at every concentration of alcohol. This difference in alcohol intake was equally significant when the rats were tested in a food-contingent, schedule-induced polydipsia situation. Further, although the TMT-lesioned animal consumed fewer calories per day in the form of alcohol, their overall daily caloric intakes were slightly higher than those of the controls. These results are interpreted as a consequence of damage to structures of the forebrain and as part of a syndrome of behavioral and neurological pathology.

Full Text

Duke Authors

Cited Authors

  • Myers, RD; Swartzwelder, HS; Dyer, RS

Published Date

  • 1982

Published In

Volume / Issue

  • 78 / 1

Start / End Page

  • 19 - 22

PubMed ID

  • 6815690

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/BF00470580


  • eng

Conference Location

  • Germany