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Acute treatment with trimethyltin alters alcohol self-selection.

Publication ,  Journal Article
Myers, RD; Swartzwelder, HS; Dyer, RS
Published in: Psychopharmacology (Berl)
1982

Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-treated rat consistently drank less alcohol than did the controls at every concentration of alcohol. This difference in alcohol intake was equally significant when the rats were tested in a food-contingent, schedule-induced polydipsia situation. Further, although the TMT-lesioned animal consumed fewer calories per day in the form of alcohol, their overall daily caloric intakes were slightly higher than those of the controls. These results are interpreted as a consequence of damage to structures of the forebrain and as part of a syndrome of behavioral and neurological pathology.

Duke Scholars

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

1982

Volume

78

Issue

1

Start / End Page

19 / 22

Location

Germany

Related Subject Headings

  • Trimethyltin Compounds
  • Trialkyltin Compounds
  • Taste
  • Social Environment
  • Psychiatry
  • Neurons
  • Muridae
  • Male
  • Hippocampus
  • Energy Intake
 

Citation

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Myers, R. D., Swartzwelder, H. S., & Dyer, R. S. (1982). Acute treatment with trimethyltin alters alcohol self-selection. Psychopharmacology (Berl), 78(1), 19–22. https://doi.org/10.1007/BF00470580
Myers, R. D., H. S. Swartzwelder, and R. S. Dyer. “Acute treatment with trimethyltin alters alcohol self-selection.Psychopharmacology (Berl) 78, no. 1 (1982): 19–22. https://doi.org/10.1007/BF00470580.
Myers RD, Swartzwelder HS, Dyer RS. Acute treatment with trimethyltin alters alcohol self-selection. Psychopharmacology (Berl). 1982;78(1):19–22.
Myers, R. D., et al. “Acute treatment with trimethyltin alters alcohol self-selection.Psychopharmacology (Berl), vol. 78, no. 1, 1982, pp. 19–22. Pubmed, doi:10.1007/BF00470580.
Myers RD, Swartzwelder HS, Dyer RS. Acute treatment with trimethyltin alters alcohol self-selection. Psychopharmacology (Berl). 1982;78(1):19–22.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

1982

Volume

78

Issue

1

Start / End Page

19 / 22

Location

Germany

Related Subject Headings

  • Trimethyltin Compounds
  • Trialkyltin Compounds
  • Taste
  • Social Environment
  • Psychiatry
  • Neurons
  • Muridae
  • Male
  • Hippocampus
  • Energy Intake