Alterations in neurotransmitter activity after acute and chronic ethanol treatment: studies of transmitter interactions.

Journal Article (Journal Article)

Acute and chronic ethanol treatment has multiple effects on the neurotransmitter systems in the nigrostriatal complex. A single dose of ethanol increases striatal dopamine release at low doses, but depresses it at high doses. In ethanol-dependent rats, dopamine release is accelerated during intoxication, but is reduced during a withdrawal syndrome. Concomitantly, high-affinity choline uptake, an index of cholinergic activity, is elevated at times when dopamine release is depressed. Changes in dopaminergic or cholinergic receptor activity do not induce or result from these effects. Neither has a role for GABA or substance P yet been implicated. The data suggest that interactions between at least two trasmitters in the caudate nucleus may occur after acute and chronic ethanol treatment.

Full Text

Duke Authors

Cited Authors

  • Hunt, WA; Majchrowicz, E; Dalton, TK; Swartzwelder, HS; Wixon, H

Published Date

  • October 1, 1979

Published In

Volume / Issue

  • 3 / 4

Start / End Page

  • 359 - 363

PubMed ID

  • 42321

International Standard Serial Number (ISSN)

  • 0145-6008

Digital Object Identifier (DOI)

  • 10.1111/j.1530-0277.1979.tb05336.x


  • eng

Conference Location

  • England