Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: dose-reponse studies.
The hippocampal afterdischarge (AD) has been suggested as an index of toxicant-induced CNS change . The present experiments report raised AD thresholds, decreased AD durations, shorter post-stimulation latencies to AD onset, decreased numbers of AD spike complexes and increased numbers of spikes/complex following alcohol administration. Results are discussed in light of single-unit data concerning alcohol effects upon hippocampal cells, and the biphasic effects of alcohol upon behavior.
Swartzwelder, HS; Johnson, CT; Cooley, BC; Howell, WE; Dyer, RS
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