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Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: dose-reponse studies.

Publication ,  Journal Article
Swartzwelder, HS; Johnson, CT; Cooley, BC; Howell, WE; Dyer, RS
Published in: Neurobehav Toxicol
1979

The hippocampal afterdischarge (AD) has been suggested as an index of toxicant-induced CNS change [1]. The present experiments report raised AD thresholds, decreased AD durations, shorter post-stimulation latencies to AD onset, decreased numbers of AD spike complexes and increased numbers of spikes/complex following alcohol administration. Results are discussed in light of single-unit data concerning alcohol effects upon hippocampal cells, and the biphasic effects of alcohol upon behavior.

Duke Scholars

Published In

Neurobehav Toxicol

ISSN

0191-3581

Publication Date

1979

Volume

1

Issue

4

Start / End Page

253 / 258

Location

United States

Related Subject Headings

  • Regression Analysis
  • Rats
  • Male
  • Hippocampus
  • Ethanol
  • Electroencephalography
  • Electric Stimulation
  • Dose-Response Relationship, Drug
  • Differential Threshold
  • Animals
 

Citation

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MLA
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Swartzwelder, H. S., Johnson, C. T., Cooley, B. C., Howell, W. E., & Dyer, R. S. (1979). Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: dose-reponse studies. Neurobehav Toxicol, 1(4), 253–258.
Swartzwelder, H. S., C. T. Johnson, B. C. Cooley, W. E. Howell, and R. S. Dyer. “Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: dose-reponse studies.Neurobehav Toxicol 1, no. 4 (1979): 253–58.
Swartzwelder HS, Johnson CT, Cooley BC, Howell WE, Dyer RS. Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: dose-reponse studies. Neurobehav Toxicol. 1979;1(4):253–8.
Swartzwelder, H. S., et al. “Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: dose-reponse studies.Neurobehav Toxicol, vol. 1, no. 4, 1979, pp. 253–58.
Swartzwelder HS, Johnson CT, Cooley BC, Howell WE, Dyer RS. Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: dose-reponse studies. Neurobehav Toxicol. 1979;1(4):253–258.

Published In

Neurobehav Toxicol

ISSN

0191-3581

Publication Date

1979

Volume

1

Issue

4

Start / End Page

253 / 258

Location

United States

Related Subject Headings

  • Regression Analysis
  • Rats
  • Male
  • Hippocampus
  • Ethanol
  • Electroencephalography
  • Electric Stimulation
  • Dose-Response Relationship, Drug
  • Differential Threshold
  • Animals