Alcohol-induced alterations in hippocampal afterdischarges and afterdischarge thresholds: dose-reponse studies.

Journal Article (Journal Article)

The hippocampal afterdischarge (AD) has been suggested as an index of toxicant-induced CNS change [1]. The present experiments report raised AD thresholds, decreased AD durations, shorter post-stimulation latencies to AD onset, decreased numbers of AD spike complexes and increased numbers of spikes/complex following alcohol administration. Results are discussed in light of single-unit data concerning alcohol effects upon hippocampal cells, and the biphasic effects of alcohol upon behavior.

Full Text

Duke Authors

Cited Authors

  • Swartzwelder, HS; Johnson, CT; Cooley, BC; Howell, WE; Dyer, RS

Published Date

  • 1979

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 253 - 258

PubMed ID

  • 553239

International Standard Serial Number (ISSN)

  • 0191-3581


  • eng

Conference Location

  • United States