Renal diseases associated with human immunodeficiency virus infection: epidemiology, clinical course, and management.


Journal Article (Review)

Human immunodeficiency virus (HIV)--associated nephropathy (HIVAN) and other glomerular lesions (e.g., immunoglobulin A nephropathy and immune complex glomerulonephritis) are frequent complications of HIV infection. These renal diseases usually present as a nephrotic syndrome with progressive loss of renal function and an increased risk of mortality. The prevalence and epidemiology of these renal lesions remain largely undefined; however, most studies agree that black race is a major risk factor for HIVAN. Observational studies have suggested that antiretroviral medications and angiotensin-converting enzyme inhibitors have beneficial effects on slowing the progression of renal disease among patients with HIVAN; however, little is known about the effect of these therapies on other renal lesions. Future research should focus on gaining a better understanding of the distribution and determinants of renal disease among HIV-infected patients as well as on performing controlled studies to test treatment strategies.

Full Text

Cited Authors

  • Szczech, LA

Published Date

  • July 1, 2001

Published In

Volume / Issue

  • 33 / 1

Start / End Page

  • 115 - 119

PubMed ID

  • 11389504

Pubmed Central ID

  • 11389504

International Standard Serial Number (ISSN)

  • 1058-4838

Digital Object Identifier (DOI)

  • 10.1086/320893


  • eng

Conference Location

  • United States