Pharmacomechanical thrombolysis of experimental pulmonary emboli. Rapid low-dose intraembolic therapy.
Journal Article
We utilized low-dose intraembolic urokinase (UK) infusions in a canine model of experimental pulmonary embolism (PE) and compared the arteriographic extent of thrombolysis with three other treatment regimens. Group 1 animals (n = 16) received the intraembolic UK infused directly into the PE offering the mechanical effect of the infusion combined with pharmacologic thrombolysis. In the group 2 animals (n = 5), UK was delivered via a guide catheter placed proximal to the clot. Group 3 animals (n = 6) were treated with a direct intraembolic saline solution infusion. Group 4 (n = 7) received only intravenous heparin. The arteriographic extent of thrombolysis was graded 1+ to 3+. The extent of thrombolysis was 2.88+ in the group 1 animals and was significantly greater than in groups 2, 3, or 4 (p = 0.003, 0.0005, and 0.0001, respectively). Fibrinogen levels did not significantly decrease with intraembolic treatment (p = 0.07). Delivery of UK directly into emboli in an experimental canine PE model appears to elicit a combined mechanical and pharmacologic effect resulting in extensive thrombolysis.
Full Text
Duke Authors
Cited Authors
- Tapson, VF; Gurbel, PA; Witty, LA; Pieper, KS; Stack, RS
Published Date
- November 1994
Published In
Volume / Issue
- 106 / 5
Start / End Page
- 1558 - 1562
PubMed ID
- 7956418
Pubmed Central ID
- 7956418
International Standard Serial Number (ISSN)
- 0012-3692
Digital Object Identifier (DOI)
- 10.1378/chest.106.5.1558
Language
- eng
Conference Location
- United States