Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene.


Journal Article

Transcription of the Saccharomyces cerevisiae copper-metallothionein gene, CUP1, inducible by copper. By analyzing deletion and fusion mutants in the CUP1 5'-flanking region, we identified two closely related, tandemly arranged copper regulatory elements. A synthetic version of one of these elements conferred efficient copper induction on a heterologous promoter when present in two tandem copies.

Full Text

Duke Authors

Cited Authors

  • Thiele, DJ; Hamer, DH

Published Date

  • April 1986

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 1158 - 1163

PubMed ID

  • 3537699

Pubmed Central ID

  • 3537699

International Standard Serial Number (ISSN)

  • 0270-7306

Digital Object Identifier (DOI)

  • 10.1128/mcb.6.4.1158


  • eng

Conference Location

  • United States