Mammalian metallothionein is functional in yeast.


Journal Article

Expression of two monkey metallothioneins in yeast leads to complementation of both known functions of the endogenous yeast copperthionein gene, namely copper detoxification and autoregulation of transcription. The metallothionein-like proteins of higher and lower eukaryotes are therefore functionally analogous despite their dissimilar primary sequences.

Full Text

Duke Authors

Cited Authors

  • Thiele, DJ; Walling, MJ; Hamer, DH

Published Date

  • February 21, 1986

Published In

Volume / Issue

  • 231 / 4740

Start / End Page

  • 854 - 856

PubMed ID

  • 3080806

Pubmed Central ID

  • 3080806

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3080806


  • eng

Conference Location

  • United States