Function and autoregulation of yeast copperthionein.


Journal Article

The CUP1 gene of yeast encodes a small, metallothionein-like protein that binds to and is inducible by copper. A gene replacement experiment shows that this protein protects cells against copper poisoning but is dispensable for normal cellular growth and development throughout the yeast life cycle. The transcription of CUP1 is negatively autoregulated. This feedback mechanism, which is mediated through upstream control sequences, may play an important role in heavy metal homeostasis.

Full Text

Duke Authors

Cited Authors

  • Hamer, DH; Thiele, DJ; Lemontt, JE

Published Date

  • May 10, 1985

Published In

Volume / Issue

  • 228 / 4700

Start / End Page

  • 685 - 690

PubMed ID

  • 3887570

Pubmed Central ID

  • 3887570

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3887570


  • eng

Conference Location

  • United States