Skip to main content
Journal cover image

A logistic regression model for measuring gene-longevity associations.

Publication ,  Journal Article
Tan, Q; Yashin, AI; De Benedictis, G; Cintolesi, F; Rose, G; Bonafe, M; Franceschi, C; Vach, W; Vaupel, JW
Published in: Clinical genetics
December 2001

The logistic regression model is a popular model for data analysis in epidemiological research. In this paper, we use this model to analyze genetic data collected from gene-longevity association studies. This new approach models the probability of observing one genotype as a function of the age of investigated individuals. Applying the model to genotype data on the TH and 3'ApoB-VNTR loci collected from an Italian centenarian study, we show how it can be used to model the different ways that genes affect survival, including sex- and age-specific influences. We highlight the advantages of this application over other available models. The application of the model to empirical data indicates that it is an efficient and easily applicable approach for determining the influences of genes on human longevity.

Duke Scholars

Published In

Clinical genetics

DOI

EISSN

1399-0004

ISSN

0009-9163

Publication Date

December 2001

Volume

60

Issue

6

Start / End Page

463 / 469

Related Subject Headings

  • Tyrosine 3-Monooxygenase
  • Sex Factors
  • Polymorphism, Genetic
  • Peptide Fragments
  • Odds Ratio
  • Models, Genetic
  • Minisatellite Repeats
  • Middle Aged
  • Male
  • Longevity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tan, Q., Yashin, A. I., De Benedictis, G., Cintolesi, F., Rose, G., Bonafe, M., … Vaupel, J. W. (2001). A logistic regression model for measuring gene-longevity associations. Clinical Genetics, 60(6), 463–469. https://doi.org/10.1034/j.1399-0004.2001.600610.x
Tan, Q., A. I. Yashin, G. De Benedictis, F. Cintolesi, G. Rose, M. Bonafe, C. Franceschi, W. Vach, and J. W. Vaupel. “A logistic regression model for measuring gene-longevity associations.Clinical Genetics 60, no. 6 (December 2001): 463–69. https://doi.org/10.1034/j.1399-0004.2001.600610.x.
Tan Q, Yashin AI, De Benedictis G, Cintolesi F, Rose G, Bonafe M, et al. A logistic regression model for measuring gene-longevity associations. Clinical genetics. 2001 Dec;60(6):463–9.
Tan, Q., et al. “A logistic regression model for measuring gene-longevity associations.Clinical Genetics, vol. 60, no. 6, Dec. 2001, pp. 463–69. Epmc, doi:10.1034/j.1399-0004.2001.600610.x.
Tan Q, Yashin AI, De Benedictis G, Cintolesi F, Rose G, Bonafe M, Franceschi C, Vach W, Vaupel JW. A logistic regression model for measuring gene-longevity associations. Clinical genetics. 2001 Dec;60(6):463–469.
Journal cover image

Published In

Clinical genetics

DOI

EISSN

1399-0004

ISSN

0009-9163

Publication Date

December 2001

Volume

60

Issue

6

Start / End Page

463 / 469

Related Subject Headings

  • Tyrosine 3-Monooxygenase
  • Sex Factors
  • Polymorphism, Genetic
  • Peptide Fragments
  • Odds Ratio
  • Models, Genetic
  • Minisatellite Repeats
  • Middle Aged
  • Male
  • Longevity