Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity.

Journal Article (Journal Article)

This article investigates the relationship between the polymorphic variations in genes associated with cardiovascular disease and longevity in the Danish population. A new procedure that combines both demographic and the individual genetic information in determining the relative risks of the observed genetic variations is applied. The sex-dependent influences can be found by introducing sex-specific population survival and incorporating the risk of gene-sex interaction. Three genetic polymorphisms, angiotensinogen M/T235, blood coagulation factor VII (FVII) R/Q353 and FVII-323ins10, manifest significant influences on survival in males, with reduced hazards of death for carriers of the angiotensinogen M235 allele, the F VII Q353 allele, and the FVII-323P10 allele. The results show that some of these genotypes associated with lower risk of CVD could also reduce the carrier's death rate and contribute to longevity. However, the presence of sex-dependent effects and the fact that major CVD-associated genes failed to impose detrimental influence on longevity lead us to concur that the aging process is highly complicated.

Full Text

Duke Authors

Cited Authors

  • Tan, Q; Yashin, AI; Bladbjerg, EM; de Maat, MP; Andersen-Ranberg, K; Jeune, B; Christensen, K; Vaupel, JW

Published Date

  • August 2001

Published In

Volume / Issue

  • 36 / 8

Start / End Page

  • 1303 - 1315

PubMed ID

  • 11602206

Electronic International Standard Serial Number (EISSN)

  • 1873-6815

International Standard Serial Number (ISSN)

  • 0531-5565

Digital Object Identifier (DOI)

  • 10.1016/s0531-5565(01)00102-4


  • eng