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Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects.

Publication ,  Journal Article
Johnson, TE; Wu, D; Tedesco, P; Dames, S; Vaupel, JW
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
August 2001

Demographic profiles of several single-gene longevity mutants of the nematode Caenorhabditis elegans reveal segmental (age-specific) effects on mortality. The mortality profiles of wild-type worms were examined across multiple replicate cultures containing 100,000 or more nematodes and found to be quite replicable, although clear environmental effects are routinely found. The combined profile of wild type was compared with those of three long-lived mutants to determine how age-specific mortality is altered by mutations in age-1, clk-1, or spe-26. In all four genotypes, death rates fit a two-stage Gompertz model better than a one-stage Gompertz; that is, mortality levels off at later ages. The largest genetic effect on mortality was that of an age-1 mutation, which lowered mortality more than fivefold at most later ages. In contrast, a spe-26 mutant had a tenfold lower mortality until approximately 2 weeks of age but ultimately achieved a higher mortality, whereas clk-1 mutants show slightly higher mortality than wild type during the fertile period, early in life, but ultimately level off at lower mortality. Each mutant thus has a distinctive profile of age-specific mortalities that could suggest the time of action of each gene.

Duke Scholars

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

August 2001

Volume

56

Issue

8

Start / End Page

B331 / B339

Related Subject Headings

  • Survival Analysis
  • Sensitivity and Specificity
  • Mutation
  • Models, Theoretical
  • Models, Animal
  • Male
  • Longevity
  • Gerontology
  • Female
  • Culture Techniques
 

Citation

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ICMJE
MLA
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Johnson, T. E., Wu, D., Tedesco, P., Dames, S., & Vaupel, J. W. (2001). Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 56(8), B331–B339. https://doi.org/10.1093/gerona/56.8.b331
Johnson, T. E., D. Wu, P. Tedesco, S. Dames, and J. W. Vaupel. “Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 56, no. 8 (August 2001): B331–39. https://doi.org/10.1093/gerona/56.8.b331.
Johnson TE, Wu D, Tedesco P, Dames S, Vaupel JW. Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. The journals of gerontology Series A, Biological sciences and medical sciences. 2001 Aug;56(8):B331–9.
Johnson, T. E., et al. “Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 56, no. 8, Aug. 2001, pp. B331–39. Epmc, doi:10.1093/gerona/56.8.b331.
Johnson TE, Wu D, Tedesco P, Dames S, Vaupel JW. Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects. The journals of gerontology Series A, Biological sciences and medical sciences. 2001 Aug;56(8):B331–B339.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

August 2001

Volume

56

Issue

8

Start / End Page

B331 / B339

Related Subject Headings

  • Survival Analysis
  • Sensitivity and Specificity
  • Mutation
  • Models, Theoretical
  • Models, Animal
  • Male
  • Longevity
  • Gerontology
  • Female
  • Culture Techniques