Plasmonics-based nanostructures for surface-enhanced Raman scattering bioanalysis.


Journal Article (Review)

Surface-enhanced Raman scattering (SERS) spectroscopy is a plasmonics-based spectroscopic technique that combines modern laser spectroscopy with unique optical properties of metallic nanostructures, resulting in strongly increased Raman signals when molecules are adsorbed on or near nanometer-size structures of special metals such as gold, silver, and transition metals. This chapter provides a synopsis of the development and application of SERS-active metallic nanostructures, especially for the analysis of biologically relevant compounds. Some highlights of this chapter include reports of SERS as an immunoassay readout method, SERS gene nanoprobes, near-field scanning optical microscopy SERS probes, SERS as a tool for single-molecule detection, and SERS nanoprobes for cellular studies.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Yan, F; Stokes, DL

Published Date

  • January 2005

Published In

Volume / Issue

  • 300 /

Start / End Page

  • 255 - 283

PubMed ID

  • 15657488

Pubmed Central ID

  • 15657488

Electronic International Standard Serial Number (EISSN)

  • 1940-6029

International Standard Serial Number (ISSN)

  • 1064-3745

Digital Object Identifier (DOI)

  • 10.1385/1-59259-858-7:255


  • eng