Integrated circuit microchip system with multiplex capillary electrophoresis module for DNA analysis


Journal Article

In this paper, we describe the use of an integrated circuit (IC) microchip system as a detector in multiplex capillary electrophoresis (CE). This combination of multiplex capillary gel electrophoresis and the IC microchip technology represents a novel approach to DNA analysis on the microchip platform. Separation of DNA ladders using a multiplex CE microsystem of four capillaries was monitored simultaneously using the IC microchip system. The IC microchip-CE system has advantages such as low cost, rapid analysis, compactness, and multiplex capability, and has great potential as an alternative system to conventional capillary array gel electrophoresis systems based on charge-coupled device (CCD) detection. © 2002 Elsevier Science B.V. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Song, JM; Mobley, J; Vo-Dinh, T

Published Date

  • August 27, 2002

Published In

Volume / Issue

  • 466 / 2

Start / End Page

  • 187 - 192

International Standard Serial Number (ISSN)

  • 0003-2670

Digital Object Identifier (DOI)

  • 10.1016/S0003-2670(02)00552-4

Citation Source

  • Scopus