Laser-induced fluorescence for esophageal cancer and dysplasia diagnosis.

Journal Article (Journal Article)

A method using laser-induced fluorescence (LIF) for in vivo cancer diagnosis of the esophagus is described. Autofluorescence of normal and malignant tissues was measured directly using a fiberoptic probe inserted through an endoscope. The measurements were performed in vivo during routine endoscopy. Measurement of the fluorescence signal from the tissue was performed using laser excitation at 410 nm. The methodology was applied to differentiate normal and malignant tumors of the esophagus. The results of this LIF approach were compared with histopathology results of the biopsy samples and indicated excellent agreement in the classification of normal and malignant tumors for the samples investigated. The LIF procedure could lead to the development of a rapid and cost-effective technique for cancer diagnosis.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Panjehpour, M; Overholt, BF

Published Date

  • February 1998

Published In

Volume / Issue

  • 838 /

Start / End Page

  • 116 - 122

PubMed ID

  • 9511800

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.1998.tb08192.x


  • eng