Detection of colon malignancy using differential normalized fluorescence

Journal Article

Laser-induced fluorescence was used for direct in-vivo diagnosis of colon malignancy without requiring biopsy. The methodology was applied in a clinical study in order to differentiate adenomatous polyps from hyperplastic polyps in the colon. The measurements were performed in vivo during routine colonoscopy. Detection of the fluorescence signal from the tissue was performed using laser excitation. This report describes the differential normalized fluorescence (DNF) procedure using the amplified spectral differences between the normalized fluorescence of polyps and normal tissue. Data related to various grades of pathology of colonic tissues are discussed. In this preliminary study, the DNF procedure provides a general trend which corresponds to severity of dysplasia associated with colon malignancy. ©2004 Copyright SPIE - The International Society for Optical Engineering.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Panjehpour, M; Overholt, BF; Buckley, PF; Edwards, DH

Published Date

  • December 1, 1996

Published In

Volume / Issue

  • 2679 /

Start / End Page

  • 26 - 33

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.237592

Citation Source

  • Scopus