The physical parameters and molecular events associated with radiation-induced lung toxicity.


Journal Article (Review)

Radiation therapy (RT) is frequently used to treat patients with tumors in and around the thorax. Clinical radiation pneumonitis is a common side effect, occurring in 5% to 20% of patients. Efforts to identify patients at risk for pneumonitis have focused on physical factors, such as dose and volume. Recently, the underlying molecular biological mechanisms behind RT-induced lung injury have come under study. Improved knowledge of the molecular events associated with RT-induced lung injury may translate into a better ability to individualized therapy. This review discusses our current understanding of the physical and molecular factors contributing to RT-induced pulmonary injury.

Full Text

Cited Authors

  • Vujaskovic, Z; Marks, LB; Anscher, MS

Published Date

  • October 2000

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 296 - 307

PubMed ID

  • 11040330

Pubmed Central ID

  • 11040330

International Standard Serial Number (ISSN)

  • 1053-4296

Digital Object Identifier (DOI)

  • 10.1053/srao.2000.9424


  • eng

Conference Location

  • United States