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Expression cloning of TGF-beta receptors.

Publication ,  Journal Article
Lin, HY; Wang, XF
Published in: Mol Reprod Dev
June 1992

Using a powerful expression cloning method in COS cells, we have cloned the TGF-beta types II and III receptors. The type III TGF-beta receptor is a membrane-bound proteoglycan with a core protein of about 110 kDa. Stable expression of the type III receptor in L6 myoblasts leads to an apparent increase in the ability of the type II receptor to bind iodinated TGF-beta 1. The cloned type II receptor has a predicted protein core of about 60 kDa with a cysteine-rich extracellular domain, a single transmembrane domain, and a functional serine/threonine kinase domain that is homologous to the activin receptor and to the C. elegans protein daf-1. These results implicate serine/threonine phosphorylation as an important mechanism of TGF-beta action.

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Published In

Mol Reprod Dev

DOI

ISSN

1040-452X

Publication Date

June 1992

Volume

32

Issue

2

Start / End Page

105 / 110

Location

United States

Related Subject Headings

  • Recombinant Proteins
  • Receptors, Transforming Growth Factor beta
  • Receptors, Cell Surface
  • Obstetrics & Reproductive Medicine
  • Humans
  • Cloning, Molecular
  • Animals
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 0601 Biochemistry and Cell Biology
 

Citation

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Lin, H. Y., & Wang, X. F. (1992). Expression cloning of TGF-beta receptors. Mol Reprod Dev, 32(2), 105–110. https://doi.org/10.1002/mrd.1080320205
Lin, H. Y., and X. F. Wang. “Expression cloning of TGF-beta receptors.Mol Reprod Dev 32, no. 2 (June 1992): 105–10. https://doi.org/10.1002/mrd.1080320205.
Lin HY, Wang XF. Expression cloning of TGF-beta receptors. Mol Reprod Dev. 1992 Jun;32(2):105–10.
Lin, H. Y., and X. F. Wang. “Expression cloning of TGF-beta receptors.Mol Reprod Dev, vol. 32, no. 2, June 1992, pp. 105–10. Pubmed, doi:10.1002/mrd.1080320205.
Lin HY, Wang XF. Expression cloning of TGF-beta receptors. Mol Reprod Dev. 1992 Jun;32(2):105–110.
Journal cover image

Published In

Mol Reprod Dev

DOI

ISSN

1040-452X

Publication Date

June 1992

Volume

32

Issue

2

Start / End Page

105 / 110

Location

United States

Related Subject Headings

  • Recombinant Proteins
  • Receptors, Transforming Growth Factor beta
  • Receptors, Cell Surface
  • Obstetrics & Reproductive Medicine
  • Humans
  • Cloning, Molecular
  • Animals
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 0601 Biochemistry and Cell Biology