TGF beta signals through a heteromeric protein kinase receptor complex.
Publication
, Journal Article
Wrana, JL; Attisano, L; Cárcamo, J; Zentella, A; Doody, J; Laiho, M; Wang, XF; Massagué, J
Published in: Cell
December 11, 1992
Transforming growth factor beta (TGF beta) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.
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Published In
Cell
DOI
ISSN
0092-8674
Publication Date
December 11, 1992
Volume
71
Issue
6
Start / End Page
1003 / 1014
Location
United States
Related Subject Headings
- Transforming Growth Factor beta
- Threonine
- Signal Transduction
- Serine
- Receptors, Cell Surface
- Protein Kinases
- Multienzyme Complexes
- Molecular Sequence Data
- Models, Biological
- Mink
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Chicago
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Wrana, J. L., Attisano, L., Cárcamo, J., Zentella, A., Doody, J., Laiho, M., … Massagué, J. (1992). TGF beta signals through a heteromeric protein kinase receptor complex. Cell, 71(6), 1003–1014. https://doi.org/10.1016/0092-8674(92)90395-s
Wrana, J. L., L. Attisano, J. Cárcamo, A. Zentella, J. Doody, M. Laiho, X. F. Wang, and J. Massagué. “TGF beta signals through a heteromeric protein kinase receptor complex.” Cell 71, no. 6 (December 11, 1992): 1003–14. https://doi.org/10.1016/0092-8674(92)90395-s.
Wrana JL, Attisano L, Cárcamo J, Zentella A, Doody J, Laiho M, et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell. 1992 Dec 11;71(6):1003–14.
Wrana, J. L., et al. “TGF beta signals through a heteromeric protein kinase receptor complex.” Cell, vol. 71, no. 6, Dec. 1992, pp. 1003–14. Pubmed, doi:10.1016/0092-8674(92)90395-s.
Wrana JL, Attisano L, Cárcamo J, Zentella A, Doody J, Laiho M, Wang XF, Massagué J. TGF beta signals through a heteromeric protein kinase receptor complex. Cell. 1992 Dec 11;71(6):1003–1014.
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
December 11, 1992
Volume
71
Issue
6
Start / End Page
1003 / 1014
Location
United States
Related Subject Headings
- Transforming Growth Factor beta
- Threonine
- Signal Transduction
- Serine
- Receptors, Cell Surface
- Protein Kinases
- Multienzyme Complexes
- Molecular Sequence Data
- Models, Biological
- Mink