TGF beta signals through a heteromeric protein kinase receptor complex.

Published

Journal Article

Transforming growth factor beta (TGF beta) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.

Full Text

Duke Authors

Cited Authors

  • Wrana, JL; Attisano, L; Cárcamo, J; Zentella, A; Doody, J; Laiho, M; Wang, XF; Massagué, J

Published Date

  • December 1992

Published In

Volume / Issue

  • 71 / 6

Start / End Page

  • 1003 - 1014

PubMed ID

  • 1333888

Pubmed Central ID

  • 1333888

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(92)90395-s

Language

  • eng