Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.

Journal Article (Journal Article)

Two regions in the immunoglobulin heavy chain locus were tested for their ability to enhance transcription of the SV40 early promoter. A portion of the intervening sequence between the heavy chain joining region (Jh) and the constant region of the mu chain (Cmu) can enhance transcription when it is cloned either 5' or 3' to the SV40 early promoter. The region between C alpha and the alpha switch site, which occurs 5' to the translocated c-myc oncogene in many murine plasmacytomas, does not show transcriptional enhancer activity in this assay.

Full Text

Duke Authors

Cited Authors

  • Mercola, M; Wang, XF; Olsen, J; Calame, K

Published Date

  • August 12, 1983

Published In

Volume / Issue

  • 221 / 4611

Start / End Page

  • 663 - 665

PubMed ID

  • 6306772

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6306772

Language

  • eng

Conference Location

  • United States