Perioperative neuroprotection


Journal Article (Review)

Recent advances in intraoperative cerebral protection have been largely restricted to refinements of existing techniques. The following points are discussed. Preliminary human evidence suggests that mild induced hypothermia can reduce ischemic damage. Barbiturates remain the best available class of pharmacologic agents for neuroprotection although the mechanism of action is not well understood. Antagonists of excitatory neurotransmission, although not yet available, continue to offer promise for eventual use as pharmacologic neuroprotectants and possibly as anesthetics. Extensive evidence from laboratory animals indicates that brain edema is sensitive to the effects of intravenous fluids on plasma osmolality but not oncotic pressure.

Full Text

Duke Authors

Cited Authors

  • Warner, DS

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 7 / 5

Start / End Page

  • 416 - 420

International Standard Serial Number (ISSN)

  • 0952-7907

Digital Object Identifier (DOI)

  • 10.1097/00001503-199410000-00006

Citation Source

  • Scopus